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Zhenguo Wen, male, born in 1982 in Lulong, Hebei Province. He obtained his Bachelor's degree in Biological Sciences from the College of Life Sciences at Nankai University in 2004 and his Ph.D. in Virology and Immunology from the Shanghai Pasteur Institute, Chinese Academy of Sciences in 2011. He has extensive experience in lentiviral vector-based pseudovirus technology, monoclonal and bispecific antibody construction, expression, and upstream/downstream process development, with both academic and industrial experience in industry-academia-research transformation. He previously served as Process Development Manager for GE Life Science Greater China (2011-2013), Associate Professor at Fujian Medical University (2014-2020), Director of the Antibody Drug Development Pilot Platform at the National-Local Joint Engineering Center of Fujian Medical University (2015-2016), and Cell Engineering and Process Development Director at Dayou Huaxia Biotechnology Group Co., Ltd. founded by Professor Lieping Chen (2017-2020). In August 2020, he joined Beijing Institute of Petrochemical Technology as the Responsible Professor for the Biopharmaceutical program.

His main research areas include: ① Development of macromolecular drug screening technologies; ② Development of high-yield engineered cell lines based on site-specific integration technology; ③ Research and development of theranostic molecular probes based on nanobodies or nanomaterials; ④ Development of specialized ligands for affinity chromatography; ⑤ Upstream and downstream process development for viral vector vaccines or subunit vaccines. He has presided over 5 provincial-level projects and enterprise-sponsored horizontal projects, published over 10 papers in domestic and international journals, and applied for 5 patents (including 4 PCT patents with 2 authorized). He was recognized as an Outstanding Young Talent in Daxing District in 2021.

I. Major Research Projects

1. Jiangsu Key R&D Program Collaboration Project: Research on Influenza Broad-Spectrum Vaccine Expressed by Chinese Hamster Ovary Cells (2021-2024), Participant
2. Enterprise-University Collaboration Project: Development of Ligands for Novel Affinity Purification Media (2021-2023), Principal Investigator
3. Enterprise-University Collaboration Project: Process Development and Industrial Application of Emerging Biotechnological Products (2021-2023), Principal Investigator
4. Research on Multifunctional Anti-Tumor Antibodies Mediating Tumor-Infiltrating Lymphocyte Generation, Fujian Natural Science Foundation (2016-2019), Principal Investigator
5. Fujian Major Project for Innovative Antibody Drug Technology, Fujian Major Project (2016-2019), Participant
6. Tumor Immunotherapy Antibody Engineering Technology Research Center Project, National Development and Reform Commission (2015-2019), Participant

II. Representative Academic Publications

1. Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naive scFv Phage Display Library. Preprint in bioRxiv 2020. doi: https://doi.org/10.1101/2020.05.19.104281. Andy Q. Yuan, Likun Zhao, Lili Bai, Qingwu Meng, Zhenguo Wen, Yanhu Li, Daqing Guo, Shanshan Zhen, Xiaojun Chen, Ji Yang, Xiaoying Xue.
2. Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice. Journal of Virology. 2017 Jan 18;91(3). pii: e01389-16. doi: 10.1128/JVI.01389-16.Ye C, Wang W, Cheng L, Li G, Wen M, Wang Q, Zhang Q, Li D, Zhou P, Su L*
3. Vif Substitution Enables Persistent Infection of Pig-Tailed Macaques by Human Immunodeficiency Virus Type 1. Journal of Virology. April 2011 ; 85:8 3767-3779; doi:10.1128/JVI.02438-10. Rajesh Thippeshappa, Patricia Polacino, Monica T. Yu Kimata, Edward B. Siwak, David Anderson, Weiming Wang, Laura Sherwood, Reetakshi Arora, Michael Wen, Paul Zhou, Shiu-Lok Hu, and Jason T. Kimata*
4. Potent and Broad Anti-HIV-1 Activity Exhibited by a Glycosyl-Phosphatidylinositol-Anchored Peptide Derived from the CDR H3 of Broadly Neutralizing Antibody PG16. Journal of Virology. 2011. 85:17 8467-8476. doi:10.1128/JVI.00520-11. Lihong Liu, Michael Wen, Weiming Wang, Shumei Wang, Lifei Yang, Yong Liu, Mengran Qian, Linqi Zhang, Yiming Shao, Jason T. Kimata, and Paul Zhou*
5. GPI-anchored single chain Fv - an effective way to capture transiently-exposed neutralization epitopes on HIV-1 envelope spike. Retrovirology. 2010; 7: 79. doi: 10.1186/1742-4690-7-79. Michael Wen, Reetakshi Arora, Huiqiang Wang, Lihong Liu, Jason T Kimata, Paul Zhou*
6. Preparation and Preliminary Functional Study of Anti-EGFR/CD3 Bispecific Antibody. Journal of Fujian Medical University 2017, 51(6):369. Che Yaojian, Hu Yan, Yang Fengyun, Wen Zhenguo*
7. Establishment of Ultra Performance Liquid Chromatography Method for Quantitative Detection of FMU100 Antibody. Journal of Fujian Medical University 2017, 51(5):298. Hu Yan, Luo Liqun, Fang Shubin, Wen Zhenguo*
8. Development Trends of Antibody Drugs. Monoclonal Antibody Handbook. GE Healthcare Life Sciences. 2011. Wen Zhenguo, Fan Fenglin
9. Study on Characteristics and Molecular Biological Basis of Aniline-Degrading Bacteria. Journal of Nankai University (Natural Science Edition). 2004,(02) 24-28+33. Zhou Xia, Zheng Xianqiang, Tong Shumin, Wen Zhenguo, Cai Baoli, Wang Liansheng

III. Authorized Invention Patents

1. WIPO/PCT Patent, Application No.: PCT/CN2018/089672. Publication No.: WO2019/227490. Title: Compositions and methods for imaging. Inventors: Chen Lieping, Luo Liqun, Liu Qianyong, Wen Zhenguo
2. WIPO/PCT Patent, Application No.: PCT/CN2018/097175. Publication No.: WO2020/019232. Title: Compositions and methods for imaging. Inventors: Chen Lieping, Luo Liqun, Wen Zhenguo, Liu Qianyong
3. WIPO/PCT Patent, Application No.: PCT/CN2019/089571. Publication No.: WO2019/228509. Title: Compositions and methods for imaging. Inventors: Chen Lieping, Luo Liqun, Wen Zhenguo, Liu Qianyong
4. WIPO/PCT Patent, Application No.: PCT/CN2020/072572. Publication No.: WO2020/151572. Title: Anti-PD-L1 diabodies and the use thereof. Inventors: Chen Lieping, Wen Zhenguo, Luo Liqun