Beijing Key Laboratory of Enze Biomass and Fine Chemicals
? Profile
The Beijing Key Laboratory of Enze Biomass and Fine Chemicals is a key laboratory recognized by the Beijing Municipal Science & Technology Commission. It was approved for establishment in 2011. The laboratory focuses on energy conservation, environmental protection, pharmaceuticals and health, and new materials-key high-end precision industries in Beijing, which aimed at the high-quality development of Beijing's biopharmaceutical and health industry and the strategic demand for high-end "bottleneck" chemical materials. With innovative design of biopharmaceuticals and critical new materials as its core, it builds a research and development system for advanced biopharmaceutical and key materials driven by new productive forces, supporting the construction of Beijing's "China Pharmaceutical Valley" and the innovative research of China's new materials industry. The laboratory prioritizes key technologies for biopharmaceutical R&D and industrialization, intelligent manufacturing of pharmaceuticals, and high-value comprehensive utilization of olefins, promoting the high-quality development of biopharmaceuticals and chemical materials.
? Research Team
The laboratory has 21 full-time members, including 2 national-level high-level talent, 1 recipient of Beijing Great Wall Scholars Program, 1 recipient of Beijing nova program, 6 senior professional-title holders, 20 associate senior professional-title holders, and 5 intermediate professional-title holders. The team covers research areas including innovative biopharmaceutical processes and technologies, intelligent drug manufacturing, and new material monomer synthesis processes and technologies.
? Research Directions
(1) Innovative Biopharmaceutical Processes and Technologies: Leveraging the interdisciplinary platform of "Pharmaceutical, Chemical, and Equipment", we focus on key technologies for biopharmaceutical research and industrialization, conducting research on new antibody drug development, protein efficient expression system optimization, vaccine process innovation, synthetic biology applications, and intelligent biopharmaceutical production.
(2) Intelligent manufacturing of pharmaceutical processes: Conducting research on online detection, process modeling, intelligent perception, digital twin, and intelligent precision control of key quality attributes (CQAs) around key pharmaceutical unit operations such as drug crystallization, wet granulation, fluidized bed drying, and coating.
(3) New Material Monomer Synthesis Process and Technology: Focusing on the "bottleneck" technology for the comprehensive high-value utilization of olefins and key emerging materials in China, we focus on the production process and catalyst research and development of C2-C5 olefin dimerization, polymerization, aldol condensation, carbonyl synthesis esterification hydrogenation and other synthetic alcohols, aldehydes, esters and other products.
? Research Facilities
The laboratory occupies research space in Beijing Institute of Petrochemical Technology’s 3C Experimental Building, with a total area of 1916.9 m2. It is equipped with key instruments and equipment including X-ray powder diffractometer, Protein analyzer, liquid chromatography/ mass spectrometry, Ultra High Performance Liquid Chromatography, Chemisorption Analyzer, probe-type Raman spectrometer, near-infrared spectrometer, in-situ microscope, Thermal Analysis Instrument, fluid bed granulation dryer, high-efficiency coating machine, high-shear wet granulator, with an original value of RMB 8.32 million.
? Research Achievements
Supported by the National Natural Science Foundation of China, Beijing Natural Science Foundation, Beijing Science and Technology Plan, and corporate horizontal projects, the laboratory team has long been engaged in research on biopharmaceutical development and industrialization, online detection and intelligent control of key pharmaceutical processes, new material monomer synthesis processes and related catalysts. The team has developed domestically produced alkali resistant Protein A affinity chromatography medium and constructed high-yield and stable CHO chassis cells. It has overcome the problems of large measurement errors in online microscopic imaging of particle size under high solid concentration, two-dimensional particle shape detection, and incomplete transmission model of ultrasound in suspension. The related achievements have been applied in the intelligent manufacturing of military energetic materials and the research and development of new anti-cancer drugs, providing important technical support for the construction of smart factories and the localization of high-end pharmaceutical equipment. The catalysts and technologies for the hydrogenation of Decanal to produce Decanol and the synthesis of Guerbet Alcohol have been industrialized, and more than 30 sets of 30000 to 120000 tons/year industrial plants have been built in petroleum and petrochemical related enterprises.
The laboratory has undertaken over 30 national and provincial-level projects, as well as more than 80 enterprise level horizontal projects, with a total funding of over RMB 30 million. The laboratory has received awards including the First Prize for Technological Invention from the China Petroleum and Chemical Automation Application Association in 2025, and science and technology awards from the China Petroleum and Chemical Industry Federation.
